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Back pain may occur with Trelegy Ellipta. With NiceRx, you'll only pay $49 to obtain your Trelegy Ellipta, regardless of the retail price. COPD: TRELEGY 100/62.5/25 is for maintenance treatment of patients with chronic obstructive pulmonary disease (COPD). mild allergic reaction *. Chronic Obstructive Pulmonary Disease (COPD): TRELEGY ELLIPTA 100 mcg/62.5 mcg/25 mcg is used in adults for the long-term treatment of a lung disease called Chronic Obstructive Pulmonary Disease or COPD. Thrush is a fungal infection that can occur due to the use of inhaled steroids such as fluticasone, one of the drugs in Trelegy Ellipta. The actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. If youre breastfeeding, talk with your doctor before taking Trelegy Ellipta. And youll usually keep coughing up mucus. Its metabolites have minimal activity. Trelegy Ellipta is not used as a fast-acting inhaler for the relief of acute breathing emergencies. Can you take Trelegy and Symbicort together? Heres a comparison of how Trelegy Ellipta and Symbicort are alike and different. The inhaler has a counter that tells you how many doses of medication are left. umeclidinium, a long-acting muscarinic antagonist (LAMA), an anticholinergic bronchodilator that helps to block muscle tightening around your airways to improve breathing. Heart failure: Could a low sodium diet sometimes do more harm than good? (For more about anticholinergics, see Trelegy Ellipta and other anticholinergic medications right below.). Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. If theyre more severe or dont go away, talk with your doctor or pharmacist. sore throat. Oral thrush is a possible side effect of taking an inhaled steroid medication. This mild side effect is explained in more detail below in Side effect details.. Trelegy was also shown to reduce the annual rate of hospitalizations due to severe flare-ups (34% reduction vs. Anoro and 13% reduction vs. Breo). It also inhibits release of hypersensitivity mediators from mast cells such as histamine. Note: Some of the drugs listed here are used off-label to treat these specific conditions. stomach flu. Its important to note that Trelegy Ellipta is meant to be used over time to control COPD symptoms. For more information and to find out if youre eligible for support, call 888-825-5249 or visit the program website. Avg. Your doctor or pharmacist can help you take your first dose or show you the proper technique. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Based on a survey for secondary outcomes, Trelegy also improved patients health-related quality of life when compared to Breo, which included items such as daily symptoms, daily activities and perceived well-being. Note: Trelegy Ellipta is meant to be used over time to control asthma symptoms. To keep track of how long you have been using this medicine, write the date of when you open the tray on inhaler label. Review the full product information for Trelegy Ellipta here and discuss this information with your doctor or other health care provider. It works by activating adenyl cyclase, which then catalyzes a reaction from adenosine triphosphate (ATP) to cyclic 3,5,adenosine monophosphate (cyclic AMP). LAMA and LABA medicines are anticholinergic drugs that help to relax the muscles around the airways in the lungs. Finally, babies whose mothers were given the combination of fluticasone and vilanterol didnt have an increased risk of birth defects. Learn more here. With Trelegy Ellipta, there was a 97 mL improvement vs Breo and 54 mL improvement vs Anoro. These foil strips hold Trelegy Elliptas active drugs as follows: Note: After you inhale a dose of Trelegy Ellipta, be sure to rinse your mouth with water and spit out the water without swallowing. "Trelegy" is the name of the medication inside the inhaler. Use your Trelegy Ellipta inhaler at the same time every day. You can find an updated list of ingredients at the end of the manufacturers patient information. They can discuss rescue inhaler options with you. Trelegy Ellipta contains three active drug ingredients: fluticasone, vilanterol, and umeclidinium. Last updated on Oct 4, 2022. Trelegy Ellipta is a combination medication thats used to treat asthma. It is mainly eliminated via the fecal route after an intravenous dose is given. Trelegy Ellipta is contraindicated for use in people with severe milk protein allergies. Specifically, its important to avoid taking monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants while youre using Trelegy Ellipta. Its available only as a brand-name medication. The drug comes as an inhaler, Chronic obstructive pulmonary disease (COPD) is an umbrella term for conditions that cause airflow and breathing difficulties. It is usually oxidized via hydroxylation or O-dealkylation and then conjugated via glucuronidation to produce metabolites. Tell your doctor if you have glaucoma or elevated eye pressure before you start treatment. For patients who do not respond adequately to TRELEGY ELLIPTA 100/62.5/25 mcg once daily, increasing the dose to TRELEGY ELLIPTA 200/62.5/25 mcg once daily may provide additional improvement in asthma control. They arent meant to be used for sudden breathing problems caused by asthma. If you open and close the cover of the inhaler without inhaling the medication, youll lose the dose. Both Trelegy Ellipta and Breo Ellipta are dry powder inhalers. Trelegy Ellipta and Breo Ellipta both come as disposable inhalers. Avoid alcohol. So its important that you keep taking Trelegy Ellipta every day even if you dont notice a difference in your breathing right away. This is because both of these medications have a drug called an anticholinergic in them. Cyclic AMP causes bronchodilation via relaxation of bronchial muscles. Patients with severe hypersensitivity . Symbicort is also approved to treat asthma in children ages 6 years and older. Do NOT take two doses at the same time. Its not currently available in generic form. Breo (fluticasone furoate/vilanterol trifenatate), Zara Risoldi Cochrane, Pharm.D., M.S., FASCP, Combivent Respimat (ipratropium/albuterol), COPD lung vs. normal lungs in medical scans, vilanterol, which is a long-acting beta2-agonist (LABA), a bone that breaks more easily than it should, seeing halos or bright colors when looking at lights, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, one strip holds either 100 micrograms (mcg)* or 200 mcg** of fluticasone in each blister, the other strip holds 62.5 mcg of umeclidinium and 25 mcg of vilanterol in each blister, people who took Trelegy Ellipta had 15% fewer flare-ups each year than people who took fluticasone and vilanterol (two of the three drugs in Trelegy Ellipta), people who took Trelegy Ellipta had 25% fewer flare-ups each year than people who took umeclidinium and vilanterol (two of the three drugs in Trelegy Ellipta), 16% of people who took fluticasone and vilanterol, a long-acting beta2-agonist (LABA) and an, asthma symptoms arent well controlled on a long-term asthma medication such as an inhaled corticosteroid ICS), or, asthma is severe enough that it needs to be treated with both an ICS and a long-acting beta2-agonist (LABA) drug. As with most drugs, some people can have an allergic reaction after taking Trelegy Ellipta. Because it contains three medicines, it may be useful for those on a fixed-dose combination of fluticasone / vilanterol (Breo Ellipta) who need added bronchodilation, or those who are already using Breo Ellipta and Incruse Ellipta (umeclidinium) as 2 separate medicines. The following information describes dosages that are commonly used or recommended. Trelegy Ellipta Information for Consumers, Trelegy Ellipta Information for Healthcare Professionals. Rates of pneumonia were higher in patients receiving Trelegy triple therapy (8%) compared to Anoro (5%) or Breo (7%) in a 52-week study. If you dont use all 30 doses in 6 weeks, the inhaler is expired and you should throw it away. These include: Note: For more information about the potential negative effects of Trelegy Ellipta, see the Trelegy Ellipta side effects section above. Trelegy Ellipta has a half-life of between 11 and 24 hours, so it will stay in your bloodstream for up to 5 days after your last dose. Trelegy led to a superior and significant lung function (FEV1) improvement when compared to Breo and Anoro over one year. Lungs with COPD may be enlarged, have visible air pockets, or show other signs of damage in comparison to healthy lungs. It combines an inhaled corticosteroid (ICS), a long-acting muscarinic antagonist (LAMA) and long-acting beta2-adrenergic agonist (LABA). The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. In the bodybuilding, Trenbolone is more commonly used in a form of Tren Acetate. Chronic bronchitis is a. Therefore, these medications can cause some very similar side effects. Both treatment regimens were effective in controlling asthma exacerbations in 16% of people. Blocking these mediators can also decrease inflammation in the airways. It does not work fast enough to treat a bronchospasm attack. If you need financial support to pay for Trelegy Ellipta, help is available. This is compared with 3% to 7%* of people who took only fluticasone and vilanterol (two of the three ingredients in Trelegy Ellipta). After oral administration, 70% of the drug was recovered in urine and 30% was recovered in feces. However, no allergic reactions were reported as a side effect of the drug in clinical trials. Trelegy Ellipta fluticasone furoate 100 mcg / umeclidinium 62.5 mcg / vilanterol 25 mcg inhalation powder (medicine). Keep the inhaler dry and away from heat and sunlight. These lists contain examples of mild side effects that can occur with Trelegy Ellipta, with Symbicort, or with both drugs (when taken individually). These lists dont include all possible side effects. Here we look at how Trelegy Ellipta and Breo Ellipta are alike and different. There may be another medication to treat your infection that wont interact with Trelegy Ellipta. The word Ellipta refers to the specific type of dry powder inhaler that contains the drug. Trelegy Ellipta has been evaluated in the treatment of asthma or COPD in studies ranging from 12- to 52-weeks long. Trelegy Ellipta is an option for the treatment of asthma in patients not controlled on inhaled corticosteroids and long-acting beta agonists alone. For information about this, see the Trelegy Ellipta use with other drugs section below. Trelegy Ellipta is indicated for use in adults with either chronic obstructive pulmonary disease (COPD) or asthma. Research Triangle Park, NC: GlaxoSmithKline. This date is typically 1 year from the date they dispensed the medication. It is approved by the FDA for three uses: for the long-term maintenance of chronic obstructive pulmonary disease (COPD); for the daily maintenance treatment of airflow obstruction in patients with COPD; and for the maintenance treatment of asthma in adults. Higher FEV1s show better lung function, while lower FEV1s show poorer lung function. The use of Trelegy Ellipta and Breo Ellipta in treating COPD has been directly compared in a clinical study called the IMPACT trial. For example, it can differ whether you're taking an inhaled medication such as Advair (fluticasone and salmeterol) or an oral corticosteroid (e.g., prednisone ). Trelegy Ellipta can cause eye problems such as glaucoma, increased eye pressure, cataracts, blurry vision, and other vision changes. For more information, see the Trelegy Ellipta for COPD section above. This is an inhaler that dispenses the drug as a spray, which you breathe into your lungs. You shouldnt take Trelegy Ellipta with other anticholinergic medications. Tell your doctor if you are pregnant, planning a pregnancy, breastfeeding or planning to breastfeed before you start treatment. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Store Trelegy Ellipta at room temperature between 68F and 77F (20C and 25C). Trelegy Ellipta costs significantly more than Breo Ellipta. Then, take your next dose at your usual time. For information about this, see the Trelegy Ellipta use with other drugs section below. The half-life of fluticasone furoate is about 24 hours. Some people use this inhaler for asthma. Copyright 1996-2023 Drugs.com. Instead, youll use a rescue inhaler for sudden trouble breathing. Dont take more than one dose in 24 hours. These medications can be used for many different types of infections, such as bacterial, viral, or fungal. Clinical trials have shown that when a LABA is used in combination with an ICS, using the LABA does not increase the risk of asthma-related death and hospitalization. How long does Trelegy stay in your system? There have been reports of very serious allergic reactions in people with milk protein allergies who took other powder medications with lactose in them. If you have sudden trouble breathing, your doctor will likely want you to use a rescue inhaler such as albuterol (Ventolin HFA, ProAir) or levalbuterol (Xopenex). If youre pregnant or are planning to become pregnant, talk with your doctor before using Trelegy Ellipta. You can take Trelegy Ellipta in the morning or the evening, but do not take more than one inhalation per day. Note: The Food and Drug Administration (FDA) tracks side effects of drugs they have approved. A diuretic (water pill) helps your body get rid of extra water and salt. Breo comes in a powder. * This is a partial list of mild side effects from Trelegy Ellipta. Drugs.com. Some drugs can prolong (lengthen) a part of your heart rhythm called the QT interval. These lists contain examples of mild side effects that can occur with Trelegy Ellipta, with Breo Ellipta, or with both drugs (when taken individually). Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. fluticasone furoate/umeclidinium/vilanterol, chronic obstructive pulmonary disease (COPD), full product information for Trelegy Ellipta here. You should try to take your dose of Trelegy Ellipta at the same time each day. You should always consult your doctor or other healthcare professional before taking any medication. However, you should still check with your doctor or pharmacist before using any of these products while taking Trelegy Ellipta. The drugs work in the following ways to help relieve your COPD symptoms: Trelegy Ellipta should start working after your first dose. Symbicort comes as a metered dose inhaler. We comply with the HONcode standard for trustworthy health information. Symbicort has two active drug ingredients in it: budesonide and formoterol. Taking these medications together may increase your risk for side effects. The medication is in a powder form, and youll inhale it into your lungs as you take one deep breath. You should take Trelegy Ellipta according to your doctors or healthcare providers instructions. Most inhaled steroids have a beneficial effect for 12 hours. Best food forward: Are algae the future of sustainable nutrition? Its half-life is 11 hours. For this condition, your doctor may prescribe either Trelegy Ellipta 100/62.5/25 mcg or Trelegy Ellipta 200/62.5/25 mcg. You should stop taking these medications 2 weeks before you start Trelegy Ellipta treatment. For more information about Trelegy Elliptas approved uses, see the Trelegy Ellipta for COPD and Trelegy Ellipta for asthma sections below. There is an additional strength for asthma only (not for COPD) which is fluticasone furoate 200 mcg / umeclidinium 62.5 mcg / vilanterol 25mcg. Some people do feel or taste Trelegy Ellipta after taking it. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. You can take Trelegy Ellipta in the morning, afternoon or the evening, just be sure to take it at the same time each day. Trelegy Ellipta has 3 ingredients whose half-lives are between 11 and 24 hours and will stay in your circulation for up to 5 days after the last dose. Trelegy Ellipta hasnt been studied in pregnant animals either. urinary tract infection *. Keep Trelegy Ellipta in a dry place, away from sunlight and heat. Research Triangle Park, NC. Patients taking Trelegy also reported a significant improvement in their health-related quality of life based on an FDA-recognized questionnaire that measures activities, impact on daily life, and symptoms. You can also ask your pharmacist for information on how to dispose of your medication. Trelegy Ellipta contains lactose, which is a type of sugar in milk. The drug was studied and shown to be safe and effective for long-term use in people with either COPD or asthma. There are currently no generic forms of either drug. Common side effects when Trelegy is used for COPD include: upper respiratory tract infection, pneumonia, bronchitis, oral candidiasis (thrush), headache, back pain, joint pain, influenza (flu), sinusitis, sore throat, runny nose, altered taste, constipation, urinary tract infection, diarrhea, gastroenteritis, mouth/throat pain, cough, and voice hoarseness. COPD is a long-term disease in which the airways and air sacs inside the lungs become damaged or blocked, leading to difficulty breathing. Vilanterol is also minimally absorbed orally. If you develop back pain from taking Trelegy Ellipta, talk with your doctor. Do not use this medicine if you are allergic to any active ingredients (fluticasone furoate, umeclidinium, vilanterol) or inactive ingredients (lactose monohydrate [contains milk proteins], magnesium stearate). When an ICS and LABA are used together, there is not a significant increased risk in hospitalizations and death from asthma problems. No, you should never use Trelegy Ellipta as a rescue inhaler. Your doctor will be able to determine if Trelegy Ellipta is safe for you to take with your specific eye problem. It takes rough 5.5 half-lives for the body to clear most, if not all, of a substance. Instead, to treat a flare-up, your doctor will likely want you to use a rescue inhaler such as albuterol (Ventolin HFA, ProAir) or levalbuterol (Xopenex). Accessed Oct. 4, 2022 at, Trelegy Ellipta [Prescribing Information]. You should avoid using these medications for at least 2 weeks before you start Trelegy Ellipta treatment. Trelegy Ellipta contains fluticasone, which is an inhaled steroid. Trelegy Ellipta comes as an inhaler. Each inhaler has two foil strips inside it that contain blisters of the medication. Lipson DA, Barnhart F, Brealey N, et al. A certain type of diuretic called a non-potassium sparing diuretic can cause a decrease in your potassium level. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Umeclidinium is minimally orally absorbed. However, babies whose mothers were given vilanterol while pregnant did have birth defects affecting their bones. If you and your doctor determine that Trelegy Ellipta is safe and effective for you, youll likely take it long term. changes in voice quality, such as hoarseness. your medical condition and treatment and ask if there is any new information about TRELEGY ELLIPTA. Triple therapy with Trelegy also resulted in a lower rate of hospitalization due to COPD than umeclidiniumvilanterol (Anoro). And some of these side effects can become serious, such as overheating or hallucinating. There were no overdoses reported in people who took Trelegy Ellipta in clinical studies. Cardiovascular health: Insomnia linked to greater risk of heart attack. Strong cytochrome P450 3A4 inhibitors, like ketoconazole, an antifungal medicine, Monoamine oxidase inhibitors, a class of antidepressants, Anticholinergics, for example, cold or allergy medicines (Benadryl and others), FDA Approves Trelegy Ellipta (fluticasone furoate/umeclidinium/vilanterol) for the Treatment of Asthma. Trelegy Ellipta is made of three medications that work to help treat symptoms of asthma. All rights reserved. These allergic reactions can be serious. You may wonder how Trelegy Ellipta compares with other medications that are prescribed for similar uses. There have been reports of serious allergic reactions, including anaphylaxis, when people with milk allergies take Trelegy Ellipta. Trelegy Ellipta and Symbicort are both brand-name drugs. Rinse your mouth with water without swallowing after use to help prevent thrush (a yeast infection in your mouth and throat area). The word Ellipta refers to the specific type of inhaler that contains the drug. Mild side effects* of Trelegy Ellipta can include: Most of these side effects may go away within a few days or a couple of weeks. You may be able to. For information about this, see the Trelegy Ellipta use with other drugs section below. The combination of these medications can cause a problem with your heart rhythm. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Trelegy Ellipta only for the indication prescribed. Note: This list is not all-inclusive and includes only common medications that may interact with Trelegy Ellipta. The drugs are fluticasone, umeclidinium, and vilanterol. If you have a severe protein milk allergy, you shouldnt use Trelegy Ellipta. The safety of TRELEGY ELLIPTA in COPD is based on the safety data from two 12-week treatment trials with coadministration of umeclidinium and the fixed-dose combination of fluticasone furoate/vilanterol and a 52-week long-term trial of TRELEGY ELLIPTA 100/62.5/25 mcg compared with the fixed-dose combinations of fluticasone furoate/vilanterol . Trelegy Ellipta is not a rescue medicine for bronchospasm attacks and sudden breathing problems. We simply charge $49 a month per medication to cover the cost of our services. They can give you tips on how to deal with any side effects that may be bothersome. If you need a fast-acting inhaler like albuterol, contact your health care provider right away, as you should always have one on hand. Before taking Trelegy Ellipta, talk with your doctor about your health history. Step 1: Prepare a dose Wait to open the cover until you are ready to take your dose. You should use Trelegy Ellipta at the same time each day. Trelegy Ellipta is approved for long-term treatment of chronic obstructive pulmonary disease (COPD) and asthma. They may suggest other medications. Here are answers to some frequently asked questions about Trelegy Ellipta. The drug should not be used to treat acute bronchospasm associated with either COPD or asthma. https://www.drugs.com/newdrugs/fda-approves-trelegy-ellipta-fluticasone-furoate-umeclidinium-vilanterol-asthma-5350.html, https://www.gsk.com/en-gb/media/press-releases/phase-iii-captain-study-of-trelegy-ellipta-in-patients-with-asthma-meets-primary-endpoint/, https://www.gsksource.com/pharma/content/dam/GlaxoSmithKline/US/en/Prescribing_Information/Trelegy/pdf/TRELEGY-ELLIPTA-PI-PIL-IFU.PDF. Instead, youll use a rescue inhaler for sudden trouble breathing. It should be taken every day to treat your condition over a long-term period. This list does not contain all drugs that may interact with Trelegy Ellipta. That means with a half-life of 5 days, it will likely take 27.5 days-almost a whole month-for the body to clear this drug. It is safe to drink alcohol in moderation if you have COPD and use Trelegy Ellipta. Steady state occurs within 14 days of daily use. Accessed Oct. 21 at doi:10.1056/NEJMoa1713901, Trelegy Ellipta [Prescribing Information]. For more information about COPD and asthma, see the Trelegy Ellipta for COPD and Trelegy Ellipta for asthma sections above. Trelegy Ellipta can interact with several other medications. * This strength of Trelegy Ellipta is abbreviated as 100/62.5/25 mcg. Bronchodilation is important in the treatment of COPD or asthma, as it helps to let more air into the lungs and allows for easier breathing. It should be stored in the unopened foil tray until it is ready for use. Medically reviewed by Leigh Ann Anderson, PharmD. If your potassium level gets too low, you can have heart problems such as an irregular heart rhythm (a heartbeat thats too fast, too slow, or uneven). However, its possible that alcohol may worsen chronic obstructive pulmonary disease (COPD) or asthma symptoms, which Trelegy Ellipta is used to treat. It also helps keep the drug from harming the environment. monthly price at. This medication is taken as one inhalation. It's a brand-name prescription drug used for COPD or asthma in. It is used once daily to help breathing symptoms and reduce the number of asthma or COPD flare-ups over the long-term. If you develop symptoms of thrush, be sure to see your doctor. Using more than the recommended dosage of Trelegy Ellipta can lead to serious side effects. * This serious side effect is explained in more detail below in Side effect details.. In comparison, back pain only occurred in about 1% to 4%* of people who took only fluticasone and vilanterol (two of the three ingredients in Trelegy Ellipta). Because Trelegy Ellipta can also affect your heart rhythm, you shouldnt take these medications while using Trelegy Ellipta. Umeclidinium has a half-life of about 11 hours. Compared to Breo (fluticasone furoate 100 mcg / vilanterol 25 mcg), Trelegy Ellipta 100/62.5/25 mcg once daily showed a 110 mL significant improvement in FEV1 at 24 weeks. Brand-name medications usually cost more than generics. TRELEGY ELLIPTA is ready to use straight away. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. When the higher dose Trelegy Ellipta 200/62.5/25 mcg once daily was compared to Breo 200/25 mcg dual therapy, a significant improvement of 92 mL in trough FEV1 was seen for Trelegy. Lung function improvements (change from baseline in trough forced expiratory volume over one second [FEV1] at month 12) were also significant in the study. If you have a milk allergy, talk with your doctor about safe treatments for your condition. I have been on Trelegy for a couple of weeks and other inhalers for 18 years, I was short of breath yesterday after I took a puff of Trelegy, dosage is one puff per day. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. In addition to being FDA-approved to treat chronic obstructive pulmonary disease (COPD), Trelegy Ellipta is also FDA-approved to treat asthma. GSK Press Release. Your monthly Trelegy Ellipta cost savings if eligible. Fluticasone furoate is an inhaled corticosteroid that works by decreasing inflammation, which is a main component of COPD and asthma symptoms. Your doctor or pharmacist may also be able to recommend ways to help prevent a thrush infection from occurring in the future. This medication is also metabolized hepatically. A significant improvement in trough FEV1 from baseline (the primary endpoint) was demonstrated at week 24 for Trelegy Ellipta. (For more about possible side effects of Trelegy Ellipta, see the Trelegy Ellipta side effects section above.) Trelegy Ellipta is good for only 6 weeks after opening it or until the counter reads 0, meaning that no doses are remaining. Accessed Oct. 21, 2020 at https://www.gsksource.com/pharma/content/dam/GlaxoSmithKline/US/en/Prescribing_Information/Trelegy/pdf/TRELEGY-ELLIPTA-PI-PIL-IFU.PDF, FDA Approves Trelegy Ellipta (fluticasone furoate/umeclidinium/vilanterol) for the Treatment of Asthma. However, the three drugs (fluticasone, umeclidinium, and vilanterol) in Trelegy Ellipta have been studied separately. However, it is mainly metabolized by CYP2D6 and is also a substrate for the P-glycoprotein transporter. frequent urge to urinate. Once opened, the inhaler is only good for 6 weeks. Antimicrobial drugs are medications that are used to treat infections. The exact way that fluticasone works to decrease inflammation is not known. Other drugs that may prolong your QT interval include: If you take any of these medications or other drugs for your heart rhythm, talk with your doctor before you start Trelegy Ellipta treatment. Trelegy Ellipta costs significantly more than Symbicort. In studies, Trelegy has shown a positive effect on breathing tests (FEV1) with the first dose, but it may take several weeks or longer for your overall symptoms to improve in COPD or asthma. Instead, youll use a rescue inhaler for sudden trouble breathing. Beta-blockers are common medications that help decrease blood pressure and steady your heart rhythm. ** This strength of Trelegy Ellipta is abbreviated as 200/62.5/25 mcg. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre using Trelegy Ellipta. If you have glaucoma, Trelegy Ellipta may worsen your disease. Trelegy is only inhaled once per day because the medication effect lasts for at least 24 hours. (To learn more, see the Trelegy Ellipta side effects section above.). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Other combination medications that may be used to treat asthma include: Other medications that may be used to treat asthma include: Note: Trelegy Ellipta and the alternative drugs listed here are meant to be used over time to control asthma symptoms. Using Trelegy Ellipta for a long time can raise eye pressure, worsen glaucoma, and cause cataracts (cloudiness in the eyes). These metabolites are either minimally active or have not yet been studied to determine activity. Note: You shouldnt use Trelegy Ellipta to treat sudden breathing problems caused by COPD or asthma.