[Effect of L-carnitine on post-stress metabolism in surgical patients]. 2008;(2):CD003917. Insomnia, headaches and vertigo are common side effects. Sweets, treats, and desserts are high in added sugars and saturated fats. Clin Physiol 1984;4(4):363-365. J Pharmacol Exp Ther 1999;290:1482-92. Mantero MA, Barbero M, Giannini R, and et al. View abstract. Nefrologia. Quality of life during and between hemodialysis treatments: role of L- carnitine supplementation. Mikhailova, T. L., Sishkova, E., Poniewierka, E., Zhidkov, K. P., Bakulin, I. G., Kupcinskas, L., Lesniakowski, K., Grinevich, V. B., Malecka-Panas, E., Ardizzone, S., D'Arienzo, A., Valpiani, D., Koch, M., Denapiene, G., Vago, G., Fociani, P., Zerbi, P., Ceracchi, M., Camerini, R., and Gasbarrini, G. Randomised clinical trial: the efficacy and safety of propionyl-L-carnitine therapy in patients with ulcerative colitis receiving stable oral treatment. Famularo, G., Moretti, S., Alesse, E., Trinchieri, V., Angelucci, A., Santini, G., Cifone, G., and De, Simone C. Reduction of glutamate levels in HIV-infected subjects treated with acetylcarnitine. [v] View abstract. View abstract. In children, L-carnitine has most often been used in doses of 50-100 mg/kg by mouth daily, for up to one year. View abstract. Am Heart J 2000;139:S120-3. Kidney Blood Press Res. Acta Paediatr 1995;84:93-5. 2010;106(4):296-301. A., and Farok, M. Assessment of puberty in relation to L-carnitine and hormonal replacement therapy in beta-thalassemic patients. Nausea Diarrhea Vomiting Skin rash Less common side effects of Garcinia cambogia include: Mania/psychosis [ 88, 89, 90, 91, 92] Hallucinations, delusions, and impaired coordination [ 93] Heart problems (irregular heart rate, heart muscle damage, and heart failure) [ 94, 95] Serious muscle damage (rhabdomyolysis) [ 96, 97, 98] Metabolic rates vary by individual. Cardiology 2006;106(4):215-223. Dealberto, M. J. Valproate-induced hyperammonaemic encephalopathy: review of 14 cases in the psychiatric setting. Does L carnitine coffee make you lose weight? View abstract. J Physiol Biochem. Brevetti G, Chiariello M, Policicchio A, and et al. View abstract. Malaguarnera M, Cammalleri L, Gargante MP, et al. Russell, S. Carnitine as an antidote for acute valproate toxicity in children. Medically reviewed by Drugs.com on Jun 6, 2022. 1991;13(1-2):135-146. Yeh, Y. Y., Cooke, R. J., and Zee, P. Impairment of lipid emulsion metabolism associated with carnitine insufficiency in premature infants. Z., and McIntyre, R. S. Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders? Reprod Biol Endocrinol. View abstract. Latifian S, Hamdi K, Totakneh R. Effect of addition of l-carnitine in polycystic ovary syndrome (PCOS) patients with clomiphene citrate and gonadotropin resistant. Am.J Alzheimers.Dis Other Demen. View abstract. Sabry, A. Jones, S., Reed, C. A., Vijay, S., Walter, J. H., and Morris, A. View abstract. View abstract. Metabolic effects of continuous or acute carnitine administration with special reference to fat oxidation and nitrogen utilization. Can carnitine cause insomnia? Cell Biochem.Funct. 2006;114(1):1-7. Med.Sci Monit. Signorelli, S. S., Fatuzzo, P., Rapisarda, F., Neri, S., Ferrante, M., Oliveri, Conti G., Fallico, R., Di, Pino L., Pennisi, G., Celotta, G., and Anzaldi, M. Propionyl-L-carnitine therapy: effects on endothelin-1 and homocysteine levels in patients with peripheral arterial disease and end-stage renal disease. 2010;105(6):1338-1345. Carnitine deficiency disorders in children. Low Blood Pressure. View abstract. Clin Trials J 1990;27:155-163. View abstract. Japanese J.Physical Fitness Sports Med. Conditioned nutritional requirements and the pathogenesis and treatment of myocardial failure. A., and Morrow, G. R. Pharmacologic treatment of cancer-related fatigue. L-carnitine may aid weight loss. Ellaway CM, Williams K, Leonard H, et al. Kubota K, Uojima H, Shao X, et al. 1998;32(2):258-264. Mondillo, S., Faglia, S., D'Aprile, N., Mangiacotti, L., Campolo, M. A., Agricola, E., and Palazzuoli, V. [Therapy of arrhythmia induced by myocardial ischemia. 2006;16(4):281-287. View abstract. View abstract. Tamamogullari N, Silig Y, Icagasioglu S, Atalay A. Carnitine deficiency in diabetes mellitus complications. Changes in physical performance of untrained volunteers: effects of L-carnitine. View abstract. View abstract. Neurochem.Res. Hooshmand, S., Balakrishnan, A., Clark, R. M., Owen, K. Q., Koo, S. I., and Arjmandi, B. H. Dietary l-carnitine supplementation improves bone mineral density by suppressing bone turnover in aged ovariectomized rats. Statistical evaluation of long-term L-carnitine therapy in hyperlipoproteinaemias. Plioplys AV, Plioplys S. Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome. View abstract. L-Carnitine in maintenance hemo- dialysis clinical, lipid and biochemical effects. This information may not fit your specific health circumstances. Drug Dev Res 1988;14:213-216. Current Therapeutic Research 1986;39(3):429-435. Ovidius University Annals, Physical Education and Sport/Science, Movement and Health Series 2010;10(Suppl 2):504-507. J Intern Med 1993;233:94. View abstract. Acute and chronic effects of propionyl-L-carnitine on the hemodynamics, exercise capacity, and hormones in patients with congestive heart failure. View abstract. El-Beshlawy, A., El, Accaoui R., Abd El-Sattar, M., Gamal El-Deen, M. H., Youssry, I., Shaheen, N., Hamdy, M., El-Ghamrawy, M., and Taher, A. Do not mix citicoline with levodopa, a medication used to treat Parkinson's disease, without talking to your doctor. Here are several other types of carnitine: For most people, acetyl-L-carnitine and L-carnitine seem to be the most effective for general use. 2008;21(11):1231-1237. [L-carnitine: safe and effective for asthenozoospermia]. The main dietary sources of L-carnitine are meat, fish and some other animal products, such as milk. View abstract. When taken by mouth: L-carnitine is likely safe when taken for up to 12 months. Cuturic, M., Abramson, R. K., Moran, R. R., and Hardin, J. W. Clinical outcomes and low-dose levocarnitine supplementation in psychiatric inpatients with documented hypocarnitinemia: a retrospective chart review. European multicenter study on propionyl-L-carnitine in intermittent claudication. More research is needed on long-term benefits for healthy individuals. Eidi, M., Pouyan, O., Shahmohammadi, P., Saeidi, H., Bahar, M., and Eidi, A. As with any supplement, you should speak with your doctor before taking L-carnitine. View abstract. View abstract. Biochem Pharmacol 1995;49:1403-10. Sangouni AA, Sasanfar B, Ghadiri-Anari A, Hosseinzadeh M. Effect of l-carnitine supplementation on liver fat content and cardiometabolic indices in overweight/obese women with polycystic ovary syndrome: A randomized controlled trial. Role of L-carnitine in apnea of prematurity: a randomized, controlled trial. Most people tolerate L-carnitine well. View abstract. Int J Sport Nutr Exerc.Metab 2000;10(2):199-207. View abstract. Nephron 55 (1990): 28-32. Clin Drug Investig. J Ren Nutr 2021;S1051-2276(21)00091-1. These symptoms are not considered to be severe side effects. Warady, B. 2009;47(9):748-753. View abstract. View abstract. Sood, A., Barton, D. L., Bauer, B. 2006;30(5):421-425. View abstract. Duranay, M., Akay, H., Yilmaz, F. M., Senes, M., Tekeli, N., and Yucel, D. Effects of L-carnitine infusions on inflammatory and nutritional markers in haemodialysis patients. L-carnitine supplementation for the management of fatigue in patients with hypothyroidism on levothyroxine treatment: a randomized, double-blind, placebo-controlled trial. Drugs 1999;58:479-87. Mantovani, G. Randomised phase III clinical trial of 5 different arms of treatment on 332 patients with cancer cachexia. However, you should always pick the form thats best for your personal needs and goals. Asbaghi O, Kashkooli S, Amini MR, et al. Bull.Exp.Biol.Med. Depression, forgetfulness, "brain fog", and dark circles under the eyes are other common symptoms of AFS. Clin Hemorheol.Microcirc. The effect of combined L-carnitine and erythropoietin administration on the anaemia and on the lipid profile of patients on hemodialysis [abstract]. View abstract. A., Iezhitsa, I. N., Kravchenko, M. S., Pisarev, V. B., and Snigur, G. L. Effects of L-, D-, and DL-carnitine on morphometric parameters of skeletal muscle and exercise performance of laboratory animals receiving carnitine-deficient diet. Sip or eat the mixture slowly. View abstract. 2006;12(5):261-262. Effects of exercise intensity and altered substrate availability on cardiovascular and metabolic responses to exercise after oral carnitine supplementation in athletes. Reprod Nutr Develop 1988;28:1317-27. Am.J Clin Oncol. Malaguarnera, M., Vacante, M., Avitabile, T., Malaguarnera, M., Cammalleri, L., and Motta, M. L-Carnitine supplementation reduces oxidized LDL cholesterol in patients with diabetes. Am J Clin Nutr 1980;33(7):1489-1492. View abstract. Is there a special pill or food out there? Lagioia, R., Scrutinio, D., Mangini, S. G., Ricci, A., Mastropasqua, F., Valentini, G., Ramunni, G., Totaro, Fila G., and Rizzon, P. Propionil-L-carnitine: a new compound in the metabolic approach to the treatment of effort angina. L-Carnitine Tartrate Supplementation for 5 Weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial. 1992;141(11):379-384. View abstract. Nasser, M., Javaheri, H., Fedorowicz, Z., and Noorani, Z. Carnitine supplementation for inborn errors of metabolism. Kidney Int 1990;38:912-8. Amino.Acids 2009;36(2):365-372. Int J Fertil 1977;22:85-91. Yet, there are a few known side effects that include agitation, insomnia and nausea. 1 It has been reported to cause vomiting, diarrhea, a fishy body odor, abdominal cramps, and nausea. You may report side effects to FDA at 1-800-FDA-1088. 1989;4(5):366-371. Castro-Gago M, Eiris-Punal J, Novo-Rodriguez MI, et al. 7 Best Creatine Supplements for Women in 2023: A Dietitians Picks. Safety, tolerability and symptom outcomes associated with L-carnitine supplementation in patients with cancer, fatigue, and carnitine deficiency: a phase I/II study. B., Das, A. M., DeKlerk, J. Musso, G., Gambino, R., Cassader, M., and Pagano, G. A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Sugino, T., Aoyagi, S., Shirai, T., Kajimoto, Y., and Kajimoto, O. 2010;34(3):295-299. Zhonghua Nan.Ke.Xue. Eur J Urol 1996;30(Suppl 2):954. View abstract. 2009;19(3):212-216. However, L-carnitine supplements may raise your blood levels of trimethylamine-N-oxide (TMAO) over time. Hiatt, W. R., Creager, M. A., Amato, A., and Brass, E. P. Effect of propionyl-L-carnitine on a background of monitored exercise in patients with claudication secondary to peripheral artery disease. L-Carnitine supplementation in older women. Res.Dev.Disabil. View abstract. View abstract. Galvano, F., Li, Volti G., Malaguarnera, M., Avitabile, T., Antic, T., Vacante, M., and Malaguarnera, M. Effects of simvastatin and carnitine versus simvastatin on lipoprotein(a) and apoprotein(a) in type 2 diabetes mellitus. Although the cause of depression is unclear, scientists have hypothesized that depression may be partly caused by the overactivation of the HPA axis - the part of the nervous system that responds to stress. Ramos AC, Elias PR, Barrucand L, Da Silva JA. 2013;8(1):e53707. View abstract. Cacciatore L, Cerio R, Ciarimboli M, et al. Wang Y, Xu Y, Zou R, et al. Carnitine deficiency induced by pivampicillin and pivmecillinam therapy. Malaguarnera, M., Vacante, M., Motta, M., Giordano, M., Malaguarnera, G., Bella, R., Nunnari, G., Rampello, L., and Pennisi, G. Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial. Does L-carnitine reduce belly fat? 10-21-2011;17(39):4414-4420. Zelnik N, Fridkis I, Gruener N. Reduced carnitine and antiepileptic drugs: cause relationship or co-existence? Prolonged oral L-carnitine substitution increases bicycle ergometer performance in patients with severe, ischemically induced cardiac insufficiency. View abstract. Toxicol Res (Camb). View abstract. J Psychiatr.Pract. Curr Ther res, Clin exp 1982;32(11):116-127. View abstract. 2010;7:16. View abstract. View abstract. Biomed Pharmacother. 2011;28(4):393-400. View abstract. View abstract. The efficacy of combined l-carnitine and l-acetyl carnitine in men with idiopathic oligoasthenoteratozoospermia: A systematic review and meta-analysis. 2008;28(8):495-500. The Effects of L-Carnitine, Acetyl-L-Carnitine, and Propionyl-L-Carnitine on Body Mass in Type 2 Diabetes Mellitus Patients. Interestingly, food sources of L-carnitine have a greater absorption rate than supplements. Gibault, J. P., Frey, A., Guiraud, M., Schirardin, H., Bouletreau, P., and Bach, A. C. Effects of L-carnitine infusion on intralipid clearance and utilization. Saudi.J Kidney Dis Transpl. The standard dose of L-carnitine is 5002,000 mg per day. Shortland, G. J., Walter, J. H., Stroud, C., Fleming, P. J., Speidel, B. D., and Marlow, N. Randomised controlled trial of L-carnitine as a nutritional supplement in preterm infants. Nat Med. Dutta, A., Ray, K., Singh, V. K., Vats, P., Singh, S. N., and Singh, S. B. L-carnitine supplementation attenuates intermittent hypoxia-induced oxidative stress and delays muscle fatigue in rats. 1987;1(4):238-241. View abstract. WebMD does not provide medical advice, diagnosis or treatment. View abstract. A pilot study. 2006;8(3-4):404-416. 2009;41(11):840-845. View abstract. View abstract. Rossignol, D. A. View abstract. Kuwasawa-Iwasaki M, Io H, Muto M, et al. Unexpected awakening from comatose thyroid storm after a single intravenous injection of L-carnitine. 2011;17(7):H55-H59. View abstract. View abstract. Caruso U, Leone L Cravotto E Nava D. Effects of L-carnitine on anemia in aged hemodialysis patients treated with recombinant human erythropoietin: A pilot study. View abstract. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease. View abstract. Obstet.Gynecol. Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. 2019;14(6):504-514. A., Bromberg, M. B., Chan, G. M., and Kissel, J. T. SMA CARNI-VAL trial part I: double-blind, randomized, placebo-controlled trial of L-carnitine and valproic acid in spinal muscular atrophy. 11-15-2008;102(10):1413-1417. View abstract. Curr Med Res Opin. L-Carnitine may cause serious side effects. Eur J Nutr 2022;61(3):1199-1207. (More information) If you choose to take L-carnitine supplements, the Linus Pauling Institute recommends acetyl-L-carnitine at a daily dose of 0.5 to 1 g. Obstet.Gynecol. It seems l carnitine is a relatively safe nutrient in doses ranging from 50 to 500 mg. Higher doses may lead to excess energy, restlessness, perhaps insomnia. Am J Kidney Dis 1995;26(5):757-764. Research suggests that L-carnitine may aid exercise performance and treat health conditions like heart disease and type 2 diabetes. 2011;22(6):1155-1159. Clin Trials J 1988;25:227-237. The effect of preoperative L-carnitine supplementation on myocardial metabolism during aorto-coronary-bypass surgery. Naturally produced in the body, acetyl-L-carnitine is also widely available in drugstores, supermarkets and health food catalogs as a . Pesce, V., Fracasso, F., Cassano, P., Lezza, A. M., Cantatore, P., and Gadaleta, M. N. Acetyl-L-carnitine supplementation to old rats partially reverts the age-related mitochondrial decay of soleus muscle by activating peroxisome proliferator-activated receptor gamma coactivator-1alpha-dependent mitochondrial biogenesis. According to this work, published online in the journal Nature Medicine, eating red meat delivers L-carnitine to bacteria that live in the human gut. Helms, R. A., Mauer, E. C., Hay, W. W., Jr., Christensen, M. L., and Storm, M. C. Effect of intravenous L-carnitine on growth parameters and fat metabolism during parenteral nutrition in neonates. Acta Haematol. J Pediatr Hematol Oncol. Int J Clin Pharmacol Res 1992;12(3):149-157. L-carnitine and platelet aggregation in uremic patients subjected to hemodialysis. View abstract. J.Reprod.Infertil 2010;10(4):245-251. (Chinese) 2005;11:761-764. El Beshlawy, A., Abd, El Raouf, Mostafa, F., Talaat, M., Isma'eel, H., Aoun, E., Hoffbrand, A. V., and Taher, A. Diastolic dysfunction and pulmonary hypertension in sickle cell anemia: is there a role for L-carnitine treatment? Am J Cardiol 1994;74:125-30. Cui, G., Xu, W. H., and Wu.G.P. View abstract. 2008;118(5):281-290. However, some individuals may experience digestive side effects when taking L-carnitine. Cattaneo CI, Ressico F, Valsesia R, D'Innella P, Ballabio M, Fornaro M. Sudden valproate-induced hyperammonemia managed with L-carnitine in a medically healthy bipolar patient: Essential review of the literature and case report. Life Sci 1996;59:1579-99. Karl M, Rubenstein M, Rudnick C, Brejda J. Mantovani, G., Maccio, A., Madeddu, C., Gramignano, G., Serpe, R., Massa, E., Dessi, M., Tanca, F. M., Sanna, E., Deiana, L., Panzone, F., Contu, P., and Floris, C. Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results. Eur Heart J 1989;10(6):502-508. 2012;1:CD008427. L-carnitine is an amino acid that is naturally produced in the body. J Cardiol 1991;21(2):493-504. View abstract. View abstract. View abstract. Weschler, A., Aviram, M., Levin, M., Better, O. S., and Brook, J. G. High dose of L-carnitine increases platelet aggregation and plasma triglyceride levels in uremic patients on hemodialysis. Cureus. Moradi, M., Moradi, A., Alemi, M., Ahmadnia, H., Abdi, H., Ahmadi, A., and Bazargan-Hejazi, S. Safety and efficacy of clomiphene citrate and L-carnitine in idiopathic male infertility: a comparative study. Med Sci Sports Exerc. Hsieh, C. T., Hwu, W. L., Huang, Y. T., Huang, A. C., Wang, S. F., Hu, M. H., and Chien, Y. H. Early detection of glutaric aciduria type I by newborn screening in Taiwan. J Inherit.Metab Dis 2008;31 Suppl 2:S453-S456. Romano, M., Vacante, M., Cristaldi, E., Colonna, V., Gargante, M. P., Cammalleri, L., and Malaguarnera, M. L-carnitine treatment reduces steatosis in patients with chronic hepatitis C treated with alpha-interferon and ribavirin. Baudouin C, Labb A, Liang H, Pauly A, Brignole-Baudouin F. Preservatives in eyedrops: the good, the bad and the ugly. Mate, A., Miguel-Carrasco, J. L., Monserrat, M. T., and Vazquez, C. M. Systemic antioxidant properties of L-carnitine in two different models of arterial hypertension. 2011;46(6):750-759. J Clin Lipidology 2012;6:150-158. Be sure to have your blood checked regularly. Ramos AC, Barrucand L, Elias PR, et al. Krahenbuhl S. Carnitine metabolism in chronic liver disease. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. View abstract. View abstract. A., and Loprinzi, C. L. A critical review of complementary therapies for cancer-related fatigue. A., Kraemer, W. J., Hatfield, D. L., Vingren, J. L., Fragala, M. S., Ho, J. Y., Thomas, G. A., Hakkinen, K., and Volek, J. S. Effects of L-carnitine L-tartrate supplementation on muscle oxygenation responses to resistance exercise. Ann.Clin Lab Sci 2009;39(4):399-404. View abstract. 2007;8(4):241-250. 1-1-2010;84(1):52-58. Hiatt WR, Regensteiner JG, Creager MA, et al. View abstract. A., Pollard, P., Dumez, H., del Muro, X. G., and Paz-Ares, L. Phase II randomized study of Plitidepsin (Aplidin), alone or in association with L-carnitine, in patients with unresectable advanced renal cell carcinoma. Socha, P., Horvath, A., Vajro, P., Dziechciarz, P., Dhawan, A., and Szajewska, H. Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: a systematic review. View abstract. Your L-carnitine levels are influenced by how much youre eating and how much your body is producing. Dig.Dis Sci 2006;51(12):2242-2247. J Cardiopulm.Rehabil.Prev. 2010;15(2):200-211. 2007;110(2 Pt 2):480-482. Kang, H. C., Kim, H. D., Lee, Y. M., and Han, S. H. Landau-Kleffner syndrome with mitochondrial respiratory chain-complex I deficiency. Yet, there are a few known side effects that include agitation, insomnia and nausea. Rodriguez DR, endible A, Gomez N, and et al. Baek SM, Zheng R, Seo EJ, Hwang DY, Kim BH. 2006;85(5):1409-1414. Your metabolism determines how many calories you burn each day. BJU.Int. View abstract. El Sharkwy I, Sharaf El-Din M. l-Carnitine plus metformin in clomiphene-resistant obese PCOS women, reproductive and metabolic effects: a randomized clinical trial. Kidney Blood Press Res. Common L-carnitine side effects include stomach pain, nausea, vomiting and diarrhea. Zeitschrift fr Orthomolekulare Medizin 2009;7(3):22-24. Arch Dis.Child Fetal Neonatal Ed 1998;78(3):F185-F188. View abstract. Cai, H., Yi, W., Li, M., and et al. A. Am.J Kidney Dis 1999;34(4):678-687. The effect of carnitine in patients using artificial pacemakers. In one study, 2 grams of L-carnitine reduced fatigue and increased muscle function in older adults. A few more health benefits have been linked to L-carnitine supplements. Carnitine is naturally present in many foodsespecially foods of animal originand is available as a dietary supplement. Acta Urol Ital 1996;10(3):185-187. View abstract. Dimitriadis, F., Tsambalas, S., Tsounapi, P., Kawamura, H., Vlachopoulou, E., Haliasos, N., Gratsias, S., Watanabe, T., Saito, M., Miyagawa, I., and Sofikitis, N. Effects of phosphodiesterase-5 inhibitors on Leydig cell secretory function in oligoasthenospermic infertile men: a randomized trial. It is usually taken in doses from 1000 to 2000 milligrams per day . Siami, G., Clinton, M. E., Mrak, R., Griffis, J., and Stone, W. Evaluation of the effect of intravenous L-carnitine therapy on function, structure and fatty acid metabolism of skeletal muscle in patients receiving chronic hemodialysis. The effect of L-carnitine and isoflavone supplementation on weight reduction and visceral fat accumulation in overweight women. Shojaei, M., Djalali, M., Khatami, M., Siassi, F., and Eshraghian, M. Effects of carnitine and coenzyme Q10 on lipid profile and serum levels of lipoprotein(a) in maintenance hemodialysis patients on statin therapy. View abstract. Eur J Appl Physiol Occup Physiol 1990;61:486-90. L-Carnosine Dosage. [Ref], Very common (10% or more): Anemia (12%)[Ref], Common (1% to 10%): Kidney failure (chronic hemodialysis patients)[Ref], Common (1% to 10%): Parathyroid disorder[Ref], Very common (10% or more): Pharyngitis (27%), cough increase (18%), dyspnea (11%), rhinitis (11%), Common (1% to 10%): Bronchitis, sinusitis[Ref], Common (1% to 10%): Amblyopia, eye disorder[Ref], Common (1% to 10%): Urinary tract infection[Ref], Very common (10% or more): Hypertension (21%), hypotension (19%), Common (1% to 10%): Atrial fibrillation, arrhythmia, cardiovascular disorder, electrocardiogram abnormal, palpitations, tachycardia, vascular disorder[Ref], Common (1% to 10%): Allergic reaction[Ref], Common (1% to 10%): Depression, anxiety, drug dependence, insomnia[Ref], Very common (10% or more): Infection (24%)[Ref]. View abstract. 2014 Jul 21;14:88. Ricci, A., Caiati, C., Galantino, A., Scrutinio, D., Valentini, G., Chiddo, A., and Rizzon, P. [Acute effects of propionyl-L-carnitine on anomalies of parietal kinetics of the left ventricle induced by atrial pacing in patients with ischemic heart disease. Int.J Vitam.Nutr.Res. Gynecol Endocrinol 2019;35(8):701-5. doi: 10.1080/09513590.2019.1576622. Specific populations may benefit from L-carnitine supplements. View abstract. 2010;42(10):1809-1818. View abstract. View abstract. [Short-term medication of L-carnitine before intracytoplasmic sperm injection for infertile men with oligoasthenozoospermia]. 2020;27(3):e229-e234. View abstract. Calandrella, N., De, Seta C., Scarsella, G., and Risuleo, G. Carnitine reduces the lipoperoxidative damage of the membrane and apoptosis after induction of cell stress in experimental glaucoma. Reprod.Biomed.Online. The effect of L-carnitine (carnitene) on myocardial metabolism of patients with coronary artery disease. View abstract. China Tropical Med 2007;7(5):753-754. Pediatr.Hematol.Oncol. View abstract. Vitali, G., Parente, R., and Melotti, C. Carnitine supplementation in human idiopathic asthenospermia: clinical results. Since L-carnitine helps move more fatty acids into your cells to be burned for energy, you might think this would increase your ability to burn fat and lose weight. 2005;25(7):470-477. Sato S, Namisaki T, Furukawa M, et al. Eur J Appl Physiol Occup Physiol 1985;54:131-5. J Med.Food 2006;9(4):468-473. Call your doctor for medical advice about side effects. Biol Neonate 1990;58:81-8. Indian J Clin Biochem 1992;7:19-21. Cardiovasc Drugs Ther 1998;12:291-9. View abstract. [Clinical efficacy of intravenous L-carnitine in patients with right-sided heart failure induced by pulmonary arterial hypertension]. Sawicka AK, Hartmane D, Lipinska P, Wojtowicz E, Lysiak-Szydlowska W, Olek RA. View abstract. Derosa, G., Maffioli, P., Ferrari, I., D'Angelo, A., Fogari, E., Palumbo, I., Randazzo, S., and Cicero, A. F. Orlistat and L-carnitine compared to orlistat alone on insulin resistance in obese diabetic patients. Superiority of L-propionylcarnitine vs L-carnitine in improving walking capacity in patients with peripheral vascular disease: an acute, intravenous, double-blind, cross-over study. Side Effects. View abstract. . Eroglu, H., Senel, O., and Guzel, N. A. Q. Insomnia (unable to sleep). JPEN J Parenter.Enteral Nutr 1988;12(6):555-562. Nutr Res 1997;17:405-414. 150mg ala, and 500mg carnitine. Shi, J. J Med.Toxicol. Arch.Pharm Res 2012;35(11):1945-1952. Am J Clin Nutr 1989;49(2):283-289. Available for Android and iOS devices. Eur Heart J 1996;17:414-20. Crentsil, V. Mechanistic contribution of carnitine deficiency to geriatric frailty. View abstract. Interaction with zidovudine. AIDS 2004;18:1549-60. View abstract. 2000;10(5):247-251. 2012;4:CD006282. A double-blinded, crossover study. Journal of New Drugs 1966;6(6):351-353. del Olmo, J. In a 90-day study, people with alcohol addictions who took 2 grams of acetyl-L-carnitine per day experienced significant improvements in all measures of brain function (38). Zilleruelo, G., Novak, M., Hsia, S. L., Goldberg, R., Abitbol, C., Monkus, E., and Strauss, J. Medical treatment to improve sperm quality. Taking too much (2 to 3 grams . [Infantile encephalopathy associated with the MELAS A3243G mutation. Zhonghua Nan.Ke.Xue 2012;18(5):428-431. View abstract. L-Carnosine - not to be confused with the popular supplement, L-carnitine - is a highly effective anti-aging nutrient that possesses powerful antioxidant, free radical scavenging and neurotransmitter properties. Freeman JM, Vining EPG, Cost S, Singhi P. Does carnitine administration improve the symptoms attributed to anticonvulsant medications? Marthaler NP, Visarius T, Kupfer A, Lauterburg BH. Drugs Aging 2003;20:761-7. 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